Stereoselective multicomponent synthesis of [3-(5-substituted 2-methoxyphenyl)-5-aryl-2-phenyltetrahydro-4-isoxazolyl](2-thienyl)methanones via 1,3-dipolar cycloaddition

✍ Scribed by V. Sridharan; S. Muthusubramanian; S. Pon Saravanakumar

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2005
• Tongue: English
• Weight: 154 KB
• Volume: 42
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570420407

✦ Synopsis

Three-component stereoselective synthesis of a set of new tetra substituted isoxazolidines from 5-substituted 2-methoxybenzaldehydes, N-phenylhydroxylamine and 1-(2-thienyl)-3-arylprop-2-en-1-ones has been achieved. The effect of microwave irradiation on the reaction under solvent-free conditions has also been investigated. The stereochemistry of the final products has been confirmed by NMR and single crystal X-ray analysis.