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Stereoselective Mannich reactions catalyzed by Tröger’s base derivatives in aqueous media

✍ Scribed by Hui Wu; Xiu-mei Chen; Yu Wan; Ling Ye; Hai-qiang Xin; Hua-hong Xu; Cai-hui Yue; Li-ling Pang; Rui Ma; Da-qing Shi

Book ID
104096131
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
164 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

A Tröger's base derivative (5,12-dimethyl-3,10-diphenyl-1,3,4,8,10,11-hexaazatetracyclo [6.6.1.0 2,6 .0 9,13 ] pentadeca-2(6),4,9(13),11-tetraenes) was used as an efficient catalyst for the three-component Mannich reactions of aromatic aldehydes and aromatic amines with ketones in water at room temperature. This rapid reaction afforded the corresponding b-amino ketones in good yields with excellent stereoselectivity.

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