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Stereoselective liquid chromatographic determination of 1′-oxobufuralol and 1′-hydroxybufuralol in rat liver microsomal fraction using hollow-fiber liquid-phase microextraction for sample preparation

✍ Scribed by Thiago Barth; Rodrigo A. Simões; Mônica T. Pupo; Laura T. Okano; Pierina S. Bonato


Book ID
118284889
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
249 KB
Volume
34
Category
Article
ISSN
1615-9306

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## Abstract A three‐phase hollow‐fiber liquid‐phase microextraction method for the analysis of rosiglitazone and its metabolites __N__‐desmethyl rosiglitazone and ρ‐hydroxy rosiglitazone in microsomal preparations is described for the first time. The drug and metabolites HPLC determination was carr