✦ LIBER ✦
Stereoselective intramolecular radical addition of polyhaloacyl pendant groups to the 1,3-dihydro-2-imidazolone moiety: the chiral synthesis of threo-diaminocarboxylic acids
✍ Scribed by Tomokazu Katahira; Tadao Ishizuka; Hirofumi Matsunaga; Takehisa Kunieda
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 81 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The intramolecular Ru(II)-catalyzed radical addition of trichloroacetyl and 2,2-dichloro-4-hexenoyl pendant groups to a 1,3-dihydro-2-imidazolone moiety provides a perfectly stereocontrolled approach to the preparation of 1,2-diamines which contain contiguous multi-stereocenters. Typical examples for this approach are given by the chiral synthesis of vicinal-diaminocarboxylic acids, which are amino analogs of statine and MeBmt.