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Stereoselective intramolecular aldol condensation of secoketones obtained from grayanotoxin-II

✍ Scribed by Zenzaburo Kumazawa; Ryozo Iriye


Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
200 KB
Volume
11
Category
Article
ISSN
0040-4039

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✦ Synopsis


Grayanotoxin-II (1) and its dihydroderivatives can be oxidized with leadtetraacetate to corresponding secoketones which easily isomerize by alkaline treatment into respective tetrahydroxyketones (2).

This paper deals with a circumstantial examination of the isomerization reaction towards both secoketone(1) and secoketone triacetate(I1) obtained from Grayanotoxin-II and its triacetate respectively, and also with the stereochemis-