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Stereoselective Interactions of a Specialized Antibody with Cholesterol and Epicholesterol Monolayers

✍ Scribed by David Izhaky; Lia Addadi

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 135 KB
Volume: 6
Category: Article
ISSN: 0947-6539
DOI: 10.1002/(sici)1521-3765(20000303)6:5<869::aid-chem869>3.0.co;2-l

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✦ Synopsis

The stereoselective recognition by monoclonal antibodies of two-dimensional monolayers of cholesterol spread at the air-water interface is presented. Using immunofluorescence, we show that one antibody, raised and selected against crystals of cholesterol monohydrate, specifically recognizes monolayers of cholesterol, but not monolayers of epicholesterol--its epimeric form. This demonstrates that stereoselective recognition also applies to protein-surface interactions.

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