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Stereoselective hydroxylation of a peptide side chain. The synthesis of the echinocandin right-half equivalent

โœ Scribed by Masahiro Sakaitani; Yasufumi Ohfune


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
270 KB
Volume
30
Category
Article
ISSN
0040-4039

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A stereoselective synthesis of brassinolide, which involves construction of the side chain by highly stereoselective aldol reaction of 20S-6b-methoxy-3a,5-cyclo-5a-pregnane-20-carboxadehyde 5 with the anion of a-silyloxy ketone 6 is described.