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Stereoselective hydrolysis of O-acetyl propranolol as prodrug in rat tissue homogenates

โœ Scribed by Koichi Takahashi; Satoko Tamagawa; Jun Haginaka; Hiroyuki Yasuda; Toyoshi Katagi; Nobuyasu Mizuno

Book ID
102409264
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
237 KB
Volume
81
Category
Article
ISSN
0022-3549

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Characterization of esterases involved i
Characterization of esterases involved in the stereoselective hydrolysis of ester-type prodrugs of propranolol in rat liver and plasma
โœ Yasushi Yoshigae; Teruko Imai; Megumi Taketani; Masaki Otagiri ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 84 KB ๐Ÿ‘ 1 views

An inhibition study showed that the stereoselective hydrolysis of butyryl propranolol (butyryl PL) in rat liver microsomes and plasma involves carboxylesterase. The hydrolysis of (S)-butyryl PL in plasma was specifically inhibited by eserine and bis-nitrophenyl phosphate (BNPP), compared to the (R)-