Stereoselective degradation kinetics of tebuconazole in rabbits

✍ Scribed by Wentao Zhu; Jing Qiu; Ziheng Dang; Chunguang Lv; Guifang Jia; Li Li; Zhiqiang Zhou

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 300 KB
• Volume: 19
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.20340

✦ Synopsis

Abstract

Tebuconazole[(RS)‐1‐p‐chlorophenyl‐4,4‐dimethyl‐3‐(1__H__‐1,2,4‐triazol‐1‐ylmethyl)pentan‐3‐ol] is a potent triazole fungicide and consists of a pair of enantiomers. The enantioselective degradation kinetics of tebuconazole was investigated in rabbits by intravenous (iv) injection. The concentrations of (−)‐(R)‐tebuconazole and (+)‐(S)‐tebuconazole in plasma and tissues were determined by HPLC with a cellulose tris(3,5‐dimethylphenylcarbamate)‐based chiral stationary phase. Enantioselective analysis methods for this fungicide in plasma and tissues were developed and validated. Good linearities were obtained over the concentration range of 0.25–25 mg/l for both enantiomers. The degradation followed pseudo‐first‐order kinetics and the degradation of the (+)‐(S)‐tebuconazole was much faster than that of the (−)‐(R)‐tebuconazole in plasma after administration of racemic tebuconazole. This study also indicated that environmental assessment of enantiomeric degradation may be needed to fully evaluate risks of tebuconazole use. Chirality, 2007. © 2006 Wiley‐Liss, Inc.