Stereoselective cyclizations mediated by functionalized organomagnesium reagents and catalyzed by cobalt or copper salts

✍ Scribed by Florian F. Kneisel; Yasunari Monguchi; Kolja M. Knapp; Hendrik Zipse; Paul Knochel

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 80 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)00839-0

✦ Synopsis

The iodine-magnesium exchange reaction with i-PrMgCl allows a mild preparation of functionalized arylmagnesium compounds bearing a leaving group in the molecule. With the appropriate transition-metal catalyst (a copper or cobalt salt), cyclization reactions occur leading to five-or six-membered ring systems in good yields.