Stereoselective Cyclization of Highly Enantioenriched Allylsilanes with Aldehydes via Acetal Formation: New Asymmetric Access to Tetrahydropyrans and Piperidines
✍ Scribed by Suginome, Michinori; Iwanami, Taisuke; Ito, Yoshihiko
- Book ID
- 126118307
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 106 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
Functionalized allylsilanes 1-5 and aldehydes 6-8 undergo Lewis-acid mediated ring closure to afford 2,3,5-or 6-substituted tetrahydropyrans (8-15) and 2,3-substituted octahydrochromenes (16a-b) with excellent stereoselectivity. According to DFT calculations the high stereoselectivity arises from el
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