Stereoselective Construction of a Highly Functionalized Taxoid ABC-Ring System: the C2–C9 Oxa-Bridge Approach
✍ Scribed by Sylvain Hamon; Nicolas Birlirakis; Loïc Toupet; Siméon Arseniyadis
- Book ID
- 102172860
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 314 KB
- Volume
- 2005
- Category
- Article
- ISSN
- 1434-193X
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The enolate of 4-N-(tert-butyloxycarbonyl)aminobutyro-7-lacto~e 9 reacted with 2-bromo-1methylindole-3-carboxaldehyde it, the presence of stannic chloride to give the product of aldol condensation 16. Deprotection and dehydration of the latter with trifluoroacetic' acid and dimethyl sulfide followed