Stereoselective analysis of the disposition of tosufloxacin enantiomers in man

✍ Scribed by R. Minami; N. Inotsume; C. Nakamura; M. Nakano

• Book ID: 104719294
• Publisher: Springer
• Year: 1993
• Tongue: English
• Weight: 255 KB
• Volume: 45
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00315523

✦ Synopsis

The pharmacokinetics of tosufloxacin enantiomers after oral administration of racemic tosufloxacin were examined in healthy volunteers. Only small differences were observed in time to peak concentration (2.6 +/- 0.3 [mean +/- SEM] h for (+)-tosulfoxacin vs 2.4 +/- 0.2 h for (-)-tosufloxacin), elimination half-life (3.61 +/- 0.24 h vs 3.49 +/- 0.23 h), and area under the curve (2.78 +/- 0.19 h.micrograms/ml vs 2.87 +/- 0.19 h.micrograms/ml); however, peak concentration (0.40 +/- 0.03 microgram/ml vs 0.44 +/- 0.03 microgram/ml), renal clearance (226 +/- 10 ml/min vs 202 +/- 10 ml/min), and urinary recovery (35.4 +/- 2.2% vs 32.4 +/- 1.9%) differed significantly between enantiomers.