Stereoselective Aldol Coupling of α,β-Acetylenic Ketones Promoted by MgI2.
✍ Scribed by Han-Xun Wei; Jiali Hu; David W. Purkiss; Paul W. Pare
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 119 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract The efficient and highly stereoselective syntheses of a variety of (__Z__)‐configured, substituted __α__‐(hydroxymethyl)**‐**__β__‐iodo‐acrylates from prop‐2‐ynoate and various aldehydes was achieved. The synthetic protocol involves a simple one‐pot coupling reaction under mild conditio
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