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Stereoselective aldol additions to α-alkoxy aldehydes using thioester silyl ketene acetals,

✍ Scribed by Cesare Gennari; Anna Bernardi; Giovanni Poli; Carlo Scolastico


Book ID
108382641
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
226 KB
Volume
26
Category
Article
ISSN
0040-4039

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The Michael addition of a b,b-dimethyl substituted silyl ketene acetal [Me 2 C C(OMe)OSiMe 3 ] to a,b-unsaturated ketones, namely, 2-cyclopentenone, 2-cyclohexenone, 3-methyl-2-cyclohexenone, isophorone, methyl vinyl ketone and mesityl oxide occurs smoothly in the presence of the nucleophilic cataly