Stereoselective addition of organometallic reagents to β-hydroxyketones
✍ Scribed by José Luis Garcia Ruano; Amelia Tito; Rafael Culebras
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 644 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
A new asymmetric synthesis of both enantiomers of P-substituted ketones is described. Our recent investigation on the chemistry of activating a chiral protecting group by organometallic reagents' has prompted us to report a stereoselective conjugate addition of organoaluminum compounds to chiral o,
## Knoevenagel condensations between t-butylcyclohexanone and malononim' le, Meldrum' s acid and ethyl cyanoacetate gave electron-deficient alkenes which underwent equatorial-selective attack by chemoselective aryl organometallic reagents. Further transformations of the products were shown to be p
## An examination of the diastereoselective addition of vinyl organometallic reagents to N-BOC L-serinal acetonide ( ) to afford mixtures of syn-2 and anti-2 is presented. Vinylzinc chloride in nonpolar solvents was found to add to the aldehyde carbonyl of 1 with h:l synlanti stereoselectivity i