Quaternary a-amino acids a b s t r a c t Chiral symmetrical alk-2-yne-1,4-diols have been stereoselectively transformed into 5-alkyl-4-alkenyl-4phenyl-1,3-oxazolidin-2-ones, which are precursors of quaternary a-amino b-hydroxy acids. The key step was the cyclization of the bis(tosylcarbamates) of 2-
Stereoselective Addition of Grignard Reagents and Lithium Alkyls onto 3,5-Disubstituted-1,3-oxazolidine-2,4-diones
β Scribed by Galliani, Guido; Rindone, Bruno; Suarez-Bertoa, Ricardo; Saliu, Francesco; Terraneo, Alberto
- Book ID
- 119965634
- Publisher
- Taylor and Francis Group
- Year
- 2013
- Tongue
- English
- Weight
- 309 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0039-7911
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π SIMILAR VOLUMES
Grignard compounds (organomagnesium halides) are among the longest-known organometallic reagents and have found a plethora of applications in organic synthesis. [2] In particular, they are used for additions to polarized or polarizable carbon-heteroatom multiple bonds. However, they are less suitabl
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## Abstract Facile, alternative synthetic routes to **6**, **(R)β6**, and **(S)β6**β3βbenzylβ__N__β(2,6βdimethylphenyl)β1,3βoxazolidineβ4βcarboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**β, **(R)β11**β, and *