Stereoselection at the Steady State: The Design of New Asymmetric Reactions

✍ Scribed by Thomas Wirth

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 91 KB
• Volume: 37
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/(sici)1521-3773(19980817)37:15<2069::aid-anie2069>3.0.co;2-#

✦ Synopsis

Not a new principle, but a shrewd analysis of stereoconvergent reactions is leading to new and highly efficient asymmetric reactions. A prochiral compound can be converted through a clever combination of competing reactions, one of which must be stereoselective, into a sole chiral product (shown above). The strategy is reviewed by using a radical cyclization reaction as an example.