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Stereodivergent approach to α-hydroxy acids involving substrate directed reduction of α-keto amides

✍ Scribed by Sunil V. Pansare; R. Gnana Ravi


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
256 KB
Volume
36
Category
Article
ISSN
0040-4039

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Stereoselective sodium borohydride reduc
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A highly stereoselective reduction of g-oxo-a-amino acids by sodium borohydride in the presence of a catalytic amount of manganese(II) chloride gives syn-g-hydroxy-a-amino acids. Enantiomerically pure syn-(2S,4R,1 H S)-4-aryl-4-hydroxy-2-(1 H -phenylethylamino)butanoic acids form stable gels in meth