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Stereocontrolled synthesis of the taxol C-13 side chain: Methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate

✍ Scribed by Wolfgang Schade; Hans-Ulrich Reißig


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
22 KB
Volume
341
Category
Article
ISSN
1615-4150

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Synthesis of (R, S)-[2,3-13C2]-1-(1′-met
✍ Timothy W. Abraham; Edward Leete 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 317 KB 👁 1 views

2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate