✦ LIBER ✦
Stereocontrolled Synthesis of the cis-Hydroxydecalin System: Towards Biologically Active 19-nor-Clerodanes
✍ Scribed by Paul Malek Mirzayans; Rebecca H. Pouwer; Craig M. Williams; Paul V. Bernhardt
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 600 KB
- Volume
- 2012
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Abstract
The 19‐nor‐clerodanes are compact, densely functionalized diterpenes based on a stereocentre‐rich decalin scaffold. To date only a few examples of the 19‐nor‐clerodanes have been synthesized, hence new flexible strategies are required. We herein describe the stereocontrolled construction of the cis‐hydroxy decalin core in a concise fashion.