Stereocontrolled synthesis of HIV-1 protease inhibitors with C2-axis of symmetry
β Scribed by Arun K. Ghosh; Sean P. McKee; Wayne J. Thompson
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 287 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Summarv: An efficient and stereocontrolled synthesis of various Q-symmetric HIV-l protease inhibitors is described, starting from commercially available and inexpensive Dmannitol.
π SIMILAR VOLUMES
With the goal of obtaining inexpensive yet potent anti-AIDS drugs, simple inhibitors of HIV-1 protease were synthesised. The C2symmetrical pseudopeptidic substrate analogues can be prepared as inhibitors for HIV-1 protease starting from symmetrical ketones 3a-d by a facile four-step synthesis. After
The synthesis of the pseudo C2-symmetric dibenzyldiamino alcohol (S,S)-I and the two meso stereoisomers la and lb (R = PhCH2) is described by stereocontrolled benzylmagnesium chloride addition to the nitrones 3 derived from chiral ~-amino-c~-hydroxy aldehydes 2 that in turn were obtained from phenyl