A facile and stereocontrolled synthesis
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Alessandra Maria Nocioni; Carmela Papa; Claudia Tomasini
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Article
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1999
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Elsevier Science
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French
⚖ 215 KB
The diastereoselective synthesis of syn-a-alkyl a-hydroxy 13-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti a-alky113-benzoylamino acid methyl esters with iodine. The intermediate a-iodo derivatives spontaneously afforded c/s-oxazolines which, up