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Stereocontrolled synthesis of D-α-hydroxy carboxylic acid from L-amino acids

✍ Scribed by Horst Kunz; Hans-Georg Lerchen


Book ID
108382899
Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
184 KB
Volume
28
Category
Article
ISSN
0040-4039

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The diastereoselective synthesis of syn-a-alkyl a-hydroxy 13-amino acids 4a-h was easily accomplished by reaction of the sodium dianion of the corresponding anti a-alky113-benzoylamino acid methyl esters with iodine. The intermediate a-iodo derivatives spontaneously afforded c/s-oxazolines which, up