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Stereocontrolled synthesis of clerodin homolog A synthetic approach to structure-activity relationships

✍ Scribed by Yasuhiro Kojima; Natsuki Kato

Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
265 KB
Volume
21
Category
Article
ISSN
0040-4039

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✦ Synopsis

In order to elucidate the structure-activity relationships of the antifeeding diterpenes having a neo-clerodane skeleton, clerodin homolog 2 was stereoselectively synthesized through 18 steps via a key intermediate 12. -Perhydrofuro [2,3-b] furan ring In the synthesized homolog was more unstable than that of the natural product, and gave a tri-MeOH adduct 2 In a

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