1,8-Stereocontrol by 1,5-induction using
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E.Kate Dorling; Andrew P. Thomas; Eric J. Thomas
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Article
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1999
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Elsevier Science
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French
⚖ 119 KB
The relative configurations of 1,8-stereogenic centres can be controlled by coupling the tin(IV) chloride promoted reactions of aldehydes with 4-alkoxypent-2-enylstannanes, which proceed with excellent 1,5-induction, with a 2,3-Wittig rearrangement: this approach has been used to complete a diastere