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Stereocontrolled synthesis of 4- and 9-ethyl-2-azabicyclo[3.3.1]nonan-7-ones via 2-cyanopiperidines

✍ Scribed by Josep Bonjoch; Núria Casamitjana; Jordi Gràcia; Joan Bosch


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
269 KB
Volume
30
Category
Article
ISSN
0040-4039

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✍ Nemes, Peter ;Janke, Frank ;Scheiber, Pál 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB

## Abstract The azabicyclic __endo__ compound 3 was synthesized by reaction of enamine 1 with 2‐benzoyl‐1,3‐dichloropropane (2). The thermodynamically more stable __exo__ isomer 4 was obtained by epimerization of 3 with sodium methoxide. The reduction of 3 and 4 was carried out with different reduc