Stereocontrolled cyclization of enynols and allenynols with (η2-propene)Ti(O-i-Pr)2. Important role of unprotected hydroxy group at a remote position

✍ Scribed by Hirokazu Urabe; Fumie Sato

• Book ID: 104259902
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 235 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01572-x

✦ Synopsis

Stereochemistry of (r/2-propene)Ti(O-i-Pr)2-mediated cyclization of enynols and allenynols is efficiently controlled by their remote hydroxy group, showing good diastereoselectivities as high as 82:18-98.5:1.5, which are uniformly superior to those observed for the corresponding t-BuMe2Si ethers.