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Stereocontrolled aldol additions to α-methylene-β-alkoxy aldehydes: Application to the synthesis of a C13C25 segment of bafilomycin A1

✍ Scribed by Ian Paterson; Shelley Bower; Malcolm D. McLeod


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
273 KB
Volume
36
Category
Article
ISSN
0040-4039

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MgBr mediated addition of to A'and Methyl &-methylthio propionate silylketene acetal o(,p-alkoxy aldehydes is highly 3,4 syn-selective (18:l). syn-d-methylene$-hydroxy-s-alkoxy esters (6) and (8) are synthesized. We recently reported that I butyIP-dimethylamino propionate, a synthetic equivalent of