Stereochemistry of the reaction of Grignard reagents with ortho esters. Case of orbital overlap control synthesis of unstable polyalkyl-1,3-dioxanes
โ Scribed by Eliel, Ernest L.; Nader, Franz
- Book ID
- 120802234
- Publisher
- American Chemical Society
- Year
- 1969
- Tongue
- English
- Weight
- 380 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The reaction of cis-2-methoxy-4-methyl-1,3-dioxane (4) with Grignard reagents proceeds in a totally regioselective manner via rupture of the less congested C(2)-0(1) bond remote from the 4-methyl substituent. The analogous r-2-methoxy-cis-4,cis-6-dimethyi-l,3dioxane (2) is totally inert to the acti
The Stereochemistry of the Grignard -Ortho Ester Reaction Revisited: Regioselective Endocyclic Cleavage in the Reaction of Grignard Reagents with cis-2-Methoxy-4-methyl-1,3-dioxane. -cis-Dioxane (Ia) selectively reacts with Grignard reagents (cf. (II)) via rupture of the less congested C(2)-O(1) bo