Stereochemistry of SN2′ reactions
✍ Scribed by W. Drenth
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 98 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0165-0513
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## Abstract Ab initio calculations of negatively charged symmetrical and unsymmetrical transition states of the S~N~2′ reaction indicate that due to electronic reasons and particularly Coulomb interactions the __anti__ transition state is generally more stable than the __syn__ transition state. The
SN2(P) reactions of chlorophosphates, which take place with inversion of configuration, are higly dependent upon the nature of the nucleophile. On the contrary, exocyclic substitutions of five-membered ring chlorophosphates with retention show a marked kinetic levelling effect. SN2(P) processes with