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Stereochemistry of nucleic acids and polynucleotides. V. Conformational energy of a ribose-phosphale unit

โœ Scribed by A. V. Lakshminarayanan; V. Sasisekharan

Publisher
Wiley (John Wiley & Sons)
Year
1969
Tongue
English
Weight
663 KB
Volume
8
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

The potential energy calculations on the sugar-phosphate unit for different puckerings of the sugar are reported in this paper. The results obtained here essentially confirm our earlier predictions made by using criteria of contact distances (hard-sphere potential) and are also supported by observed conformation in crystal structures. The minimum energy conformations of the sugar phosphate unit, along with the preferred orientations of the base with respect to the sugar given in the previous paper, determine the probable conformations of the monomer unit of a polynucleotide (or nucleic acid) chain.

๐Ÿ“œ SIMILAR VOLUMES

Stereochemistry of nucleic acids and pol
Stereochemistry of nucleic acids and polynucleotides. IV. Conformational energy of base-sugar units
โœ A. V. Lakshminarayanan; V. Sasisekharan ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 653 KB

In this paper, the preferred conformations of the bases with respect to the sugar in various base-sugar units are worked out using criteria of potential energy. The van der Waals type of intercations between nonbonded atoms is represented by a 6-12 function and the electrostatic interactions have be

Stereochemistry of nucleic acids and pol
Stereochemistry of nucleic acids and polynucleotides. VI. Minimum energy conformations of dimethyl phosphate
โœ V. Sasisekharan; A. V. Lakshminarayanan ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 455 KB

As part of a study on the conformation of polynucleotides and nucleic acids the preferred conformations of the model conpound dimethyl phosphate are worked out using potential energy functions. In calculating the total potential energy associated with the conformation, nonbonded, torsional, and elec