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Stereochemistry, conformational analysis, and transannular cyclizations of nine-membered ring azaolefins

โœ Scribed by Wilson, Stephen R.; Sawicki, Robert A.


Book ID
118170412
Publisher
American Chemical Society
Year
1979
Tongue
English
Weight
1019 KB
Volume
44
Category
Article
ISSN
0022-3263

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The aza-Claisen rearrangement of vinylpyrrolidines 1 yielded almost exclusively the trans-3,8-disubstituted nine-membered ring lactams 2 (TBS=tBuMe Si), independent of whether cis or trans isomers were used as starting materials. The conformation (which provided facial chirality) of the medium-sized