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Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin

✍ Scribed by Assunta Giordano; Carmela Della Monica; Francesco Landi; Aldo Spinella; Guido Sodano *

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
123 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3 -dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield.

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