Stereochemistry and Dynamics of the Hydrobromide of 1-(Aminomethyl)-5,6-dihydroxyisochroman, Semi-rigid Analogue of Catecholamines

✍ Scribed by Lorenzo Di Bari; Gloria Uccello-Barretta; Clementina Manera

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 529 KB
• Volume: 34
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/(sici)1097-458x(199611)34:11<881::aid-omr982>3.0.co;2-l

✦ Synopsis

By means of several proton and I3C relaxation experimental techniques, selected internuclear distances and the rotational correlation time for 1-(aminomethyl)-5,6-dihydroxyisochroman hydrobromide were determined. The molecule dissolved in DMSO-d, does not show relevant internal motions and is found to tumble isotropically. Two different procedures for determining the cross-relaxation rates, one using mono-and biselective relaxation rates and the other following the build-up of the transient NOE, are compared. The two methods are formally equivalent, but have different advantages and drawbacks while yielding essentially the same structural picture.