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Stereochemical studies of 5-methyl-3-(substituted phenyl)-5-[(substituted phenyl) hydroxy methyl]-2-thiooxazolidin-4-ones

✍ Scribed by Gopal L. Khatik; Anang Pal; Shaikh M. Mobin; Vipin A. Nair


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
767 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis


The synthesis and stereochemical aspects of the aldol products, 5-methyl-3-(substituted phenyl)-5-[(substituted phenyl) hydroxy methyl]-2-thiooxazolidin-4-ones, are discussed.


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The title compound, C 26 H 30 O 7 , was obtained by the Grignard reaction of one molecule of 4-methoxybenzylmagnesium chloride with two molecules of 3,5-dimethoxybenzaldehyde. The two new chiral centers have the same absolute con®guration R (S), and the two hydroxyl groups, surrounded by the three b