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Stereochemical studies of 3-aryl-3-methylpiperidines of potential opioid ligand activities by high-resolution 1H and 13C NMR spectroscopy

✍ Scribed by A. F. Casy; M. A. Iorio; A. E. Madani

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
602 KB
Volume
25
Category
Article
ISSN
0749-1581

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✦ Synopsis

The 'H (270,400 MHz) and I3C (22.5,67.5 MHz) NMR spectra of a series of 2,3-3,5-and 3,6-dimethyl-3-(mhydroxy-/m-methoxy-pheny1)piperidines of proven or potential opioid ligand activity are reported. The data were analysed in terms of configuration and preferred conformation, and some key deductions were confirmed by NOED and 2 D COSY experiments. In the 3,5-dimethyl derivatives, isomers with preferred axial or equatorial 3-aryl substituents were identified.

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