Cycloaddition reactions of cephalosporin
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J. Cs. JΓ‘szberΓ©ny; J. Pitlik; Gy. Batta; K. E. KΓΆvΓ©r; K. KollΓ‘r
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Article
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1988
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John Wiley and Sons
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English
β 498 KB
A series of known and novel 2-methylenecephem derivatives were prepared and their reactions with diazomethane, phenyldiazomethane and diphenyldiazomethane were studied. The initially formed 1-pyrazolino derivatives easily underwent spontaneous loss of nitrogen, leading to 2-spirocyclopropylcephems.