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Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units

✍ Scribed by C. M. Venkatachalam

Book ID: 102761333
Publisher: Wiley (John Wiley & Sons)
Year: 1968
Tongue: English
Weight: 572 KB
Volume: 6
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1968.360061006

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✦ Synopsis

The general conformations of a system of three linked peptide units are studied, and it is found that there are three types of conformations which contain NH. . .O hydrogen bonding between the first and the third units. One of them is part of a 3lrhelix, while the other two are noiihelical. The two iionhelical conformations are very similar, and in both the cases the peptide chain turns around, reversing the direction of progress. Such a conformation can therefore occur in the region where a polypeptide chain folds back on itself, as in the cross-p structure. The method of representing these interesting tripeptide conformations in a (+,+) map is described. Examples of such hydrogen-bonded, nonhelical conformations which occur in peptides and proteins are discussed-e.g., in cyclohexaglycyl, an open tetrapeptide Gly-L-Pro-L-Leu-Gly, and in parts of the lysozyme chain.

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