✦ LIBER ✦
Stereochemical course of the enzymic amination of chloro- and bromo- fumaric acid by 3-methylaspartate ammonia-lyase
✍ Scribed by Mahmoud Akhtar; Mark A Cohen; David Gani
- Book ID
- 104227614
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 223 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Enzymic amination of chloro-and bromo-fumaric acid using 3-methylaspartate ammonia-lyase in the presence of ammonia leads to the formation of 3-chloro-and 3-bromoaspartic acid respectively;
the absolute configuration of each product is (R) at C-2 and (S) at C-3.
3-Methylaspartate
ammonia-lyase (EC 4.3.1.2) catalyses the reversible aa-elimination of ammonia from (2S,3S)-3-methylaspartic acid to give mesaconic acid, 1 Scheme 1. It is known that the enzyme is also capable of catalysing the deamination of (2S)-aspartic acid and some