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Stereochemical Assignment of the C 1 −C 6 Fragment of Psymberin by Synthesis and Natural Product Degradation

✍ Scribed by Green, Michael E.; Rech, Jason C.; Floreancig, Paul E.


Book ID
126297067
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
93 KB
Volume
7
Category
Article
ISSN
1523-7060

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Synthesis and stereochemical assignment
✍ K.C. Nicolaou; Kyo Han Ahn 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 284 KB

Compound 8 representing fhe Ct-CtO fragment of nystafin At has been synthesized from nystafin Af by degradation and by total synthesis. Comparison of the two samples revealed the 3R, 5R, 7R stereochemistry for the three nystafin A I centers. Nystatin At (I)1 is a clinically used polyene macrolide