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Stereochemical Aspects of 1,3-Butadiene Metabolism and Toxicity in Rat and Mouse Liver Microsomes and Freshly Isolated Rat Hepatocytes

✍ Scribed by Nieusma, Joe L.; Claffey, David J.; Maniglier-Poulet, Chris; Imiolczyk, Tomasz; Ross, David; Ruth, James A.


Book ID
126969723
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
304 KB
Volume
10
Category
Article
ISSN
0893-228X

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In toxicological studies hepatocytes o †er an excellent alternative to whole-animal experiments, provided their metabolic competence has been established. We have compared Phase 1 and 2 metabolism in rat, mouse, chicken and ox liver microsomes and cytosol with freshly isolated hepatocytes. The relat