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Stereo- and regioselective synthesis of 1,3-diaryl-3-chloro-1-propanols via the reaction of aryl aldehydes with styrene and (E)-β-methylstyrene

✍ Scribed by George W. Kabalka; Zhongzhi Wu; Yuhong Ju

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
100 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reactions of aryl aldehydes with styrene and (E)-b-methylstyrene in the presence of phenylboron dichloride regioselectively generate 1,3-diaryl-3-chloro-1-propanols and 1,3-diaryl-3-chloro-2-methyl-1-propanols in good to excellent yields with high stereoselectivity.

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