Stepwise sequential aneuploidy screening in clinical practice

✍ Scribed by Joseph R. Wax; Angelina Cartin; Dwight Smith; Rosemarie Smith; Renée Chard; Molly Carpenter; Michael G. Pinette

• Book ID: 102333349
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 198 KB
• Volume: 40
• Category: Article
• ISSN: 0091-2751
• DOI: 10.1002/jcu.20898

✦ Synopsis

Abstract

Purpose.

To evaluate stepwise sequential screening (SSS) efficiency in clinical practice.

Methods.

All singletons undergoing SSS in a single practice by NTQR (Nuchal Translucency Quality Review Program)‐credentialed providers in a 2‐year period were included. Prenatal diagnosis was offered to all screen‐positive women and those with a nuchal translucency ≥3.5 mm or cystic hygroma at the 11‐ to 14‐week scan. Data were extracted from prospectively ascertained serum screening and genetics databases.

Results.

A total of 2,726 patients were screened, with SSS detecting all eight cases of trisomy 21 and all seven cases of other aneuploidies at a 4.3% screen‐positive rate.

Conclusions.

Stepwise sequential screening offers excellent aneuploidy screening efficiency when introduced into clinical practice. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011