Stepwise oligogenic segregation and linkage analysis illustrated with dopamine-β-hydroxylase activity

✍ Scribed by Wilson, A. F. ;Elston, R. C. ;Sellers, T. A. ;Bailey-Wilson, J. E. ;Gersting, J. M. ;Deen, D. K. ;Sorant, A. J. M. ;Tran, L. D. ;Amos, C. I. ;Siervogel, R. M.

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 948 KB
• Volume: 35
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.1320350321

✦ Synopsis

A stepwise oligogenic method is developed that can be used to adjust the phenotype of a quantitative trait for the effects of a previously identified single-locus component. This method assumes that a single-locus component can be adequately identified through the use of segregation and/or linkage analysis under a 1-locus model and that the variation due to that locus can be removed from the phenotype leaving a residual that can be parameterized in terms of an additional single-locus component. Segregation and/or linkage analysis can then be used in an attempt to identify an additional single-locus component in the residual phenotype. This stepwise process can be repeated until no further single-locus effects are identified. The method is illustrated using family data on the specific activity of dopamine-p-hydroxylase (DBH), which a number of studies have suggested may be due either to the combined effects of singlelocus and multifactorial components or to the combined effects of 2 loci.