✦ LIBER ✦

Stepwise Gatekeeping Procedures in Clinical Trial Applications

✍ Scribed by Alex Dmitrienko; Ajit C. Tamhane; Xin Wang; Xun Chen

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 22 KB
Volume: 48
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.200610315

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Stepwise Gatekeeping Procedures in Clini

Stepwise Gatekeeping Procedures in Clinical Trial Applications

✍ Alex Dmitrienko; Ajit C. Tamhane; Xin Wang; Xun Chen 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB

Development of gatekeeping strategies in

Development of gatekeeping strategies in confirmatory clinical trials

✍ Alex Dmitrienko; Brian A. Millen; Thomas Brechenmacher; Gautier Paux 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB

Some extensions and applications of a Ba

Some extensions and applications of a Bayesian strategy for monitoring multiple outcomes in clinical trials

✍ Peter F. Thall; Hsi-Guang Sung 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 2 views

We present some practical extensions and applications of a strategy proposed by Thall, Simon and Estey for designing and monitoring single-arm clinical trials with multiple outcomes. We show by application how the strategy may be applied to construct designs for phase IIA activity trials and phase I

MULTI-LEVEL MODELS FOR REPEATED MEASUREM

MULTI-LEVEL MODELS FOR REPEATED MEASUREMENT DATA: APPLICATION TO QUALITY OF LIFE DATA IN CLINICAL TRIALS

✍ HEATHER J. BEACON; SIMON G. THOMPSON 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 985 KB

Quality of life data present considerable statistical challenges because of their longitudinal and multi- dimensional nature, and also because the available data are often very unbalanced through missing values. Here we exemplify the potential of multi-level models, that is, hierarchical random coe

Infant clinical assessment procedure: It

Infant clinical assessment procedure: Its applications for diagnosis and treatment in the second and third year

✍ Dr. Antal E. Solyom; Dr. Thomas M. Horner; Ms. Patricia Hoffman 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 781 KB

Using the bootstrap for estimation in gr

Using the bootstrap for estimation in group sequential designs: an application to a clinical trial for nasopharyngeal cancer

✍ Michael LeBlanc; John Crowley 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 2 views

We investigate a resampling method for bias correction in group sequential designs with censored survival data using logrank testing. The method draws nested bootstrap samples of di!erent sizes from the observed data in order to mimic the large sample independent increment property of statistics res