Stenotrophomonas maltophilia infection related mortality during induction in childhood acute lymphoblastic leukemia

✍ Scribed by Abbas, Adil A.H. ;Fryer, Christopher J.H. ;Felimban, Sami K. ;Yousef, Abdulmottaleb A. ;Fayea, Najwa Y. ;Osoba, Olu

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 150 KB
• Volume: 41
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.10279

✦ Synopsis

The diagnosis of NBL was based on histopathologic findings and biochemical markers, but the diagnosis of histiocytosis (LCH) was not definite, because it was based on conventional morphology alone. The unfavorable NBL factors required aggressive treatment with drugs that are active in LCH treatment as well; that is why we had no need to modify therapy at the end of which both diseases appeared to be in remission.

LCH-malignancy associations have been divided into two groups by Egeler et al. depending on the time of diagnosis [2].

One group concerns patients in whom the diagnoses were made simultaneously and the other in whom the diagnosis of one followed the other. The authors suggest that the histiocytic disorder is a reactive process in the first group, but those malignancies that developed after the treatment of LCH could be the result of chemotherapy [2]. In the present case, the NBL and histiocytosis were diagnosed simultaneously.

The question remains whether the findings in the bone marrow were a second independent disorder in the form of LCH or whether there was a histiocytic reaction to the NBL.