Stem Cells and Human Diseases

✍ Scribed by Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava (auth.), Rakesh Srivastava, Sharmila Shankar (eds.)

• Publisher: Springer Netherlands
• Year: 2012
• Tongue: English
• Leaves: 641
• Edition: 1
• Category: Library

✦ Synopsis

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

✦ Table of Contents

Front Matter....Pages i-ix
Cancer Stem Cells: Biology, Perspectives and Therapeutic Implications....Pages 1-22
The Perspectives of Stem Cell-Based Therapy in Neurological Diseases....Pages 23-60
Stem Cell-Based Therapy for Lysosomal Storage Diseases....Pages 61-90
Drosophila Germline Stem Cells....Pages 91-99
Mesenchymal Stem Cells in Hematopoietic Stem Cell Transplantation....Pages 101-115
Cancer Stem Cells in Solid Tumors, Markers and Therapy....Pages 117-148
Cancer Stem Cells: Paradigm Shifting or Perishing Concept?....Pages 149-174
Genomics of Prostate Cancer....Pages 175-196
Ischemia, Reactive Radicals, Redox Signaling and Hematopoietic Stem Cells....Pages 197-216
Cancer Stem Cell Models and Role in Drug Discovery....Pages 217-228
Origins of Metastasis-Initiating Cells....Pages 229-246
The Reduction of Callus Formation During Bone Regeneration by BMP-2 and Human Adipose Derived Stem Cells....Pages 247-266
Stem Cells and Leukemia....Pages 267-306
The Role of Adult Bone Marrow Derived Mesenchymal Stem Cells, Growth Factors and Scaffolds in the Repair of Cartilage and Bone....Pages 307-322
Worth the Weight: Adipose Stem Cells in Human Disease....Pages 323-351
Neural Crest and Hirschsprung’s Disease....Pages 353-386
Common Denominators of Self-renewal and Malignancy in Neural Stem Cells and Glioma....Pages 387-418
Stem-Like Cells from Brain Tumours or Vice Versa ?....Pages 419-431
Translating Mammary Stem Cell and Cancer Stem Cell Biology to the Clinics....Pages 433-450
Breast Cancer Stem Cells....Pages 451-465
Translin/TRAX Deficiency Affects Mesenchymal Differentiation Programs and Induces Bone Marrow Failure....Pages 467-484
Cancer Therapies and Stem Cells....Pages 485-495
Cancer Stem Cells and Head and Neck Squamous Cell Carcinomas....Pages 497-507
The Biology of Lung Cancer Stem Cells....Pages 509-532
Stem Cell Characters in Primary and Metastatic Tumour Establishment....Pages 533-580
Plasticity of Cancer Stem Cells....Pages 581-591
Cross Talks Among Notch, Wnt, and Hedgehog Signaling Pathways Regulate Stem Cell Characteristics....Pages 593-606
Global OMICs Profiling and Functional Analysis of CD44+/CD24− Stem-Like Cells in Normal Human Breast Tissue and Breast Cancer....Pages 607-626
Back Matter....Pages 627-630

✦ Subjects

Biomedicine general; Literacy; Medicine/Public Health, general; Entomology