Stem Cell Therapy for Diabetes

✍ Scribed by George K. Gittes, Krishna Prasadan, Sidhartha Tulachan (auth.), Shimon Efrat (eds.)

• Publisher: Humana Press
• Year: 2010
• Tongue: English
• Leaves: 293
• Series: Stem Cell Biology and Regenerative Medicine
• Edition: 1
• Category: Library

✦ Synopsis

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Sure to pique the interest of investigators, clinicians, and students of stem-cell application in regenerative medicine, and cell therapy of diabetes, Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

✦ Table of Contents

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Pancreas and Islet Development....Pages 3-40
Islet and Pancreas Transplantation....Pages 41-83
Cell Cycle Regulation in Human Pancreatic Beta Cells....Pages 85-103
Islet Regeneration....Pages 105-122
Beta-Cell Expansion in Vitro....Pages 123-133
Front Matter....Pages 135-135
What Does It Take to Make a Beta Cell?....Pages 137-152
Generation of Beta Cells from Acinar Cells....Pages 153-166
Generation of Beta Cells from Pancreatic Duct Cells and/or Stem Cells....Pages 167-182
Adult Cell Reprogramming: Using Nonpancreatic Cell Sources to Generate Surrogate Beta Cells for Treatment of Diabetes....Pages 183-202
Embryonic Stem Cells as a Potential Cure for Diabetes....Pages 203-220
Front Matter....Pages 221-221
Functional Tissue Reconstruction with the Use of Biologic Scaffolds....Pages 223-239
Immunoisolation in Cell Transplantation....Pages 241-262
Prevention of Islet Graft Rejection and Recipient Tolerization....Pages 263-279
Back Matter....Pages 281-291

✦ Subjects

Stem Cells; Diabetes; Cell Biology; Biotechnology