Stem Cell Genetics for Biomedical Research

✍ Scribed by Raul Delgado-Morales

• Publisher: Springer International Publishing
• Year: 2018
• Tongue: English
• Leaves: 426
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment.

In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

✦ Table of Contents

Front Matter ....Pages i-xi
Front Matter ....Pages 1-1
Human-Induced Pluripotent Stem Cell-Derived Neurons to Model and Gain Insights into Alzheimer’s Disease Pathogenesis (Jessica E. Young, Raul Delgado-Morales)....Pages 3-12
Modeling Schizophrenia with Human Stem Cells (Juliana Minardi Nascimento, Veronica M. Saia-Cereda, Giuliana S. Zuccoli, Danielle Gouvêa-Junqueira, Daniel Martins-de-Souza)....Pages 13-26
Rett Syndrome and Stem Cell Research (Keita Tsujimura, Kinichi Nakashima)....Pages 27-41
Stem Cell Applications in Spinal Cord Injury: A Primer (James Hong, Christopher E. Rodgers, Michael G. Fehlings)....Pages 43-72
Cell-Based Therapy for Retinal Degenerative Disease (Marco A. Zarbin)....Pages 73-85
Past, Present and Future of Cell-Based Therapy in Progressive Multiple Sclerosis (Giulio Volpe, Joshua D. Bernstock, Luca Peruzzotti-Jametti, Stefano Pluchino)....Pages 87-132
Front Matter ....Pages 133-133
Cardiac Stem Cells: A Plethora of Potential Therapies for Myocardial Regeneration Within Reach (Enrique Gallego-Colon, Eduardo Oliver)....Pages 135-171
Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in the Evaluation of Cardiotoxic Potential of Drugs (Yee Xiang Chang, Christine L. Mummery)....Pages 173-194
Front Matter ....Pages 195-195
Regenerative Medicine for Diabetes Treatment: New β-Cell Sources (Rosa Gasa, Meritxell Rovira)....Pages 197-220
Dental Pulp Stem Cells Promote Wound Healing and Muscle Regeneration (E. Martínez-Sarrà, S. Montori, C. Gil-Recio, R. Núñez-Toldrà, N. Carrio Bertran, A. Al Madhoun et al.)....Pages 221-240
From Bench to Bedside of Mesenchymal Stem Cells Use for Rheumatoid Arthritis Treatment (R. A. Contreras, N. Luque, F. Djouad, Roberto Elizondo-Vega, Patricia Luz-Crawford)....Pages 241-269
Stem Cells and Cancer (Meredith Davis, Katja Gassner, Ruth Rodriguez-Barrueco, David Llobet-Navas)....Pages 271-309
The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging (Dido Carrero, Carlos López-Otín)....Pages 311-334
Front Matter ....Pages 335-335
Pluripotent Stem Cell Banks (Begoña Aran, Ángel Raya, Anna Veiga)....Pages 337-367
Engineering of Human-Induced Pluripotent Stem Cells for Precise Disease Modeling (P. Lisowski)....Pages 369-411
Back Matter ....Pages 413-426

✦ Subjects

Life Sciences; Stem Cells; Human Genetics; Molecular Medicine