Stem cell factor enhances erythropoietin-mediated transactivation of signal transducer and activator of transcription 5 (STAT5) via the PKA/CREB pathway

The transcription factors signal transdu

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression

✍ Ji Hoon Yu; Bing-Mei Zhu; Mark Wickre; Gregory Riedlinger; Weiping Chen; Atsushi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 841 KB

Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that